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Gouania Longipetala Aqueous Extract Exhibits Antiestrogen Activities and Activate Estrogen Receptors in Ovariectomized Wistar Rats

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Gouania Longipetala Aqueous Extract Exhibits Antiestrogen Activities and Activate Estrogen Receptors in Ovariectomized Wistar Rats


Mengue Ngadena Yolande Sandrine | Dzeufiet Djomeni Paul Désiré



Mengue Ngadena Yolande Sandrine | Dzeufiet Djomeni Paul Désiré "Gouania Longipetala Aqueous Extract Exhibits Antiestrogen Activities and Activate Estrogen Receptors in Ovariectomized Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5, August 2021, pp.338-345, URL: https://www.ijtsrd.com/papers/ijtsrd43840.pdf

Previous studies showed that G. longipetala aqueous extract (GLAE) induced estrogenic properties in ovariectomized (Ovx) rats. The present study aimed to assess antiestrogenic activities and signaling pathways of GLAE. For that, two pharmacological tests were used to evaluate GLAE effects in ovariectomized rats treated with estradiol valerate (E2V) and a pure antiestrogen (ICI 182.780). Animals were either sham-operated or Ovx. 3-day uterotrophic assay was carried out in Ovx adult Wistar rats and GLAE effects were evaluated on the genital tract and mammary gland. Results showed that GLAE reduced significantly vaginotrophic and mammotrophic effects of estradiol valerate. Indeed, GLAE reduced by 68.72% and 62.66% respectively for 45 and 180 mg/kg the vaginal epithelial height of E2V-Ovx rats. Besides, ICI 182.780 cancelled estrogenic activities of GLAE in both genital tract and mammary gland. Overall, Gouania longipetala aqueous extract activates estrogen receptors to induce estrogen activities and exhibit antiestrogenic properties.

Estrogenic receptors, ovariectomized, ICI 182.780, estradiol valerate, Gouania longipetala


IJTSRD43840
Volume-5 | Issue-5, August 2021
338-345
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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